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Detailed Introduction
The Molecular Devices ImageXpress Pico is a compact, high-performance automated imaging system designed for high-content screening (HCS) and routine fluorescence imaging applications in modern life science laboratories. It combines powerful optical performance with user-friendly software control, making it ideal for cell biology, drug discovery, assay development, and academic research.
Unlike large-scale high-content platforms, the ImageXpress Pico is optimized for benchtop use, offering a balance between image quality, automation, and affordability. It supports a wide range of imaging modes, including brightfield, phase contrast, and fluorescence imaging, enabling researchers to capture high-quality cellular data with minimal setup complexity.
The system comes with a dedicated PC, pre-installed acquisition and analysis software, and a USB dongle for secure software licensing. This ensures plug-and-play usability and stable performance in regulated laboratory environments.
With its automated stage, fast autofocus system, and multi-channel fluorescence capabilities, the ImageXpress Pico allows users to perform consistent imaging across multi-well plates, making it highly suitable for medium-throughput screening workflows.
It is widely used in:
Cell proliferation and toxicity studies
Live/dead cell assays
Transfection efficiency analysis
Reporter gene assays
Fluorescence-based drug screening
The system is designed to reduce manual imaging variability while improving reproducibility and data integrity, which is critical for pharmaceutical and biotech research.
| Item | Specification |
|---|---|
| Product Name | Molecular Devices ImageXpress Pico |
| Imaging Modes | Brightfield, Phase Contrast, Fluorescence |
| Objective Compatibility | 2x, 4x, 10x, 20x (depending on configuration) |
| Illumination | LED-based light engine |
| Autofocus | Laser-based / software autofocus system |
| Camera Type | High-sensitivity CMOS camera |
| Resolution | Up to ~5 MP (configuration dependent) |
| Plate Compatibility | 6-well to 384-well plates |
| Z-Stack Imaging | Supported |
| Software | MetaXpress Pico / Image Acquisition Software |
| Data Analysis | Cell counting, morphology, fluorescence intensity analysis |
| Included Computer | Pre-configured workstation PC |
| License | USB dongle (hardware key protection) |
| Connectivity | USB / Ethernet |
| Operating System | Windows-based system |
| Applications | High-content screening, cell imaging, drug discovery |
| System Type | Automated benchtop imaging system |
The ImageXpress Pico system is designed for laboratories that require reliable, reproducible imaging without the complexity of large-scale HCS platforms. Its integrated workflow—from image acquisition to quantitative analysis—helps researchers accelerate experimental throughput while maintaining high data quality.
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