Thermo Scientific Corona Veo CAD with Peak 1010 Nitrogen Generator 2018

The Thermo Scientific Corona Veo RS Charged Aerosol Detector (CAD), when paired with the Peak Scientific Corona Nitrogen 1010 (Peak 1010) gas generator, constitutes a complete universal LC detection solution for non‑volatile and semi‑volatile compounds lacking UV chromophores. The Corona Veo RS employs charged aerosol detection technology in which HPLC/UHPLC column eluent is nebulized with high‑purity nitrogen, the solvent is evaporated in a heated drift tube (adjustable 5–100 °C), and the remaining non‑volatile analyte particles acquire a positive charge via corona discharge before being quantified by a high‑sensitivity electrometer. Unlike refractive index (RI) or evaporative light‑scattering detectors (ELSD), CAD provides a near‑uniform response essentially independent of molecular structure, allowing reliable quantification of sugars, carbohydrates, polymers, surfactants, phospholipids, pharmaceutical excipients, and inorganic counter‑ions—even without authenticated reference standards—within a single injection across a wide dynamic range of typically 4–5 orders of magnitude. The RS variant is optimized for rapid‑separation workflows, featuring a maximum data acquisition rate of 200 Hz to fully capture narrow UHPLC peaks, a FocusJet concentric nebulizer for improved semi‑volatile sensitivity, electronic gas‑flow control, and an integrated TTL‑controlled six‑port switching valve to divert early‑eluting matrix to waste. It operates over a mobile‑phase flow range of 0.01–2.0 mL/min, connects via USB 2.0 to Thermo Scientific Chromeleon CDS or Waters Empower, and requires a clean nitrogen or dry‑air supply at 70–80 psig (≈4.8–5.5 bar) with a typical consumption of ~4 L/min.

The companion Peak 1010 nitrogen generator is purpose‑built for Thermo Scientific Corona CAD detectors, utilizing hollow‑fiber membrane separation technology to deliver up to 5 L/min of >98 % pure dry nitrogen at 80 psi (5.5 bar)—precisely matching the CAD's gas demand. It is available either as a benchtop module (Corona 1010) for connection to an existing compressed‑air line or with an integrated scroll compressor (Corona 1010A) for standalone operation. Its compact footprint (156 × 417 × 540 mm) allows direct stacking beneath the Corona Veo RS to conserve bench space. The generator reaches operating setpoint within approximately five minutes of startup, includes front‑panel pressure indication and fault diagnostics, and eliminates the inconvenience, safety concerns, and purity/pressure variability associated with high‑pressure nitrogen cylinders. Together, the Corona Veo RS CAD and Peak 1010 nitrogen generator provide pharmaceutical QC/QA, CRO, food/beverage, and polymer‑analysis laboratories with a sensitive, reproducible, and low‑maintenance universal LC detection platform especially suited for impurity profiling, forced‑degradation studies, formulation characterization, excipient quantification, and cleaning‑validation sample analysis.

Technical Specifications